Posted by : Konstantine Monday, October 5, 2009

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Currently, I am studying for two midterms, one of which is concerned with cellular metabolic pathways and their mechanisms. Glycolysis and the citric acid cycle (known also as the Kreb's cycle, the TCA cycle or the Szent-Györgyi-Krebs cycle) are of main concern at the moment. I thought I would publish the mnemonic devices I use to memorize these pathways and their associated enzymes here, both for my own future reference and the use of anyone who needs them:

Glycolysis —

Steps of glycolysis:
Goodness Gracious Father Franklin Did Go By Picking Pumpkins to Prepare Pie
Thus, the first emphasized letter of each of the above emphasized words relates to the following steps in glycolysis:
Glucose
Glucose-6-Phosphate
Fructose-6-phosphate
Fructose-1,6-biphosphate
Dihydroxyacetone phosphate (DHAP)
Glyceraldehyde-3-phosphate
1,3-Biphosphoglycerate
3-Phosphoglycerate
2-Phosphoglycerate
Phosphoenolpyruvate
Pyruvate
The enzymes involved in the above steps can be remembered with the following memory aid:
High Profile People Act Too Glamorous, Picture Posing Every Place
Again, the first emphasized letter of each of the above emphasized words relates to the following enzymes involved in the above steps in glycolysis:
Hexokinase
Phosphofructo isomerase
Phoshofructokinase
Aldolase
Triose phosphate isomerase
Glyceraldehyde-3-phosphate dehydrogenase
Phosphoglycerokinase
Phosphoglyceromutase
Enolase
Pyruvate kinase
Pyruvate Dehydrogenation Complex (PDC) —

Cofactors most important to the pyruvate dehydrogenation complex:
TLC? Fuck No.
This corresponds to:
E1:
TPP

E2:
Lipoic Acid
Coenzyme A

E3:
FAD
NAD+
Citric Acid Cycle —

Compounds involved in cycle:
Our City Is Kept Safe and Sound From Malace
This corresponds to:
Oxalacetate
Citrate
Isocitrate
Alpha-ketoglutamate
Succinyl-coA
Succinate
Fumarate
Malate
Enzymes involved in cycle:
CAIK Sounds So Fucking Mint.
This corresponds to:
Citrate synthase
Aconitase
Iso-citrate dehydrogenase
Alpha-Ketoglutarate dehydrogenase
Succinyl-coA synthetase
Succinate dehydrogenase
Fumerase
Malate dehydrogenase
Urea Cycle —

Compounds involved in cycle:

Ordinary Careless Crappers Are Also Frivolous About Urination

This corresponds to (indented steps are either requirements or products of that step):
Ornithine
Carboamyl Phosphate
Citruline
Aspartate
Argininosuccinate
Fumarate
Arginine
Urea
Enzymes involved in cycle (OAAA are the enzymes responsible for the indented steps above):

C—OAAA
Carboamyl phosphate synthase
Ornithine transcarbamoxylase
Argininosuccinate synthase
Arginininosuccinase
Arginase
Hope these come to good use.

{ 22 comments... read them below or Comment }

  1. Replies
    1. This comment has been removed by the author.

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    2. Thank you soooooo much. Exactly what I needed.

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    3. am pretty sure u did good but here take a gold star

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    4. it was very useful atleast better than others on internet

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  2. Love it! The careless crappers helped me with urea cycle. Thanks for sharing!

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  3. wow...it can help me alot...thx...can u post some for amino acid metabolism and lipid metabolism..?

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  4. Privet. Otlichni Kanal. Ia toshe izuchaiu biochemistry I mnemonics were useful.
    Mix Russian and English lol. Great channel, you have good views on things. Cheers.

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  5. very useful!! thanks a lot!

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  6. Nice mnemonics man! You da best. Glycolysis is yo' bitch and soon iz gonna be mine 2oo.

    (*) (*)
    ('''\( O . o )/''')
    ( ) PANDA MAN GIVIN COMPLIMENTS ALL
    ( ° ) DAYYYYYYY
    / / \ \
    (__) (___)

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  7. Your post is very interesting. I have a blog about mnemonic devices and I have always used them. For example, I always use this phrase to remember the planets: My Very Energetic Mother Just Served Us Nine Pizzas. But, some people liked to use “My Very Easy Method Just Shows Us Nine Planets” or “My Very Energetic Mother Jumps Skateboards Under Nana’s Patio” (Mercury, Venus, Earth, Mars, Jupiter, Saturn, Uranus, Neptune, and Pluto). The problem now is Pluto. It was reclassified as a dwarf planet.

    Best regards,
    John from Mnemonic Devices, The Revision Guy, the blog of mnemonic devices.

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  8. Hey you have the products of the Urea Cycle out of order. This phrase puts them in order: Careless Crappers Are All/Formally Unhappy.

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  9. It so helpful. Thanks a lot.

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  10. this is extremely helpful!! thank you so much xx

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  11. Man oh man, I wish I found this when I took metabolism 2 years ago! So funny and awesome! :)

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  12. Alternative to Citric acid: Cow Is A Seriously Sexy FeMale Ox :D

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  13. citric acid: Can I keep selling sex for money officer

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  14. You have to check this video for Urea Cycle easiest way to remember
    https://youtu.be/ae3qLoCB38o

    ReplyDelete

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