Archive for October 2009

Metabolism Mnemonics

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Currently, I am studying for two midterms, one of which is concerned with cellular metabolic pathways and their mechanisms. Glycolysis and the citric acid cycle (known also as the Kreb's cycle, the TCA cycle or the Szent-Györgyi-Krebs cycle) are of main concern at the moment. I thought I would publish the mnemonic devices I use to memorize these pathways and their associated enzymes here, both for my own future reference and the use of anyone who needs them:

Glycolysis —

Steps of glycolysis:
Goodness Gracious Father Franklin Did Go By Picking Pumpkins to Prepare Pie
Thus, the first emphasized letter of each of the above emphasized words relates to the following steps in glycolysis:
Glucose
Glucose-6-Phosphate
Fructose-6-phosphate
Fructose-1,6-biphosphate
Dihydroxyacetone phosphate (DHAP)
Glyceraldehyde-3-phosphate
1,3-Biphosphoglycerate
3-Phosphoglycerate
2-Phosphoglycerate
Phosphoenolpyruvate
Pyruvate
The enzymes involved in the above steps can be remembered with the following memory aid:
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Again, the first emphasized letter of each of the above emphasized words relates to the following enzymes involved in the above steps in glycolysis:
Hexokinase
Phosphofructo isomerase
Phoshofructokinase
Aldolase
Triose phosphate isomerase
Glyceraldehyde-3-phosphate dehydrogenase
Phosphoglycerokinase
Phosphoglyceromutase
Enolase
Pyruvate kinase
Pyruvate Dehydrogenation Complex (PDC) —

Cofactors most important to the pyruvate dehydrogenation complex:
TLC? Fuck No.
This corresponds to:
E1:
TPP

E2:
Lipoic Acid
Coenzyme A

E3:
FAD
NAD+
Citric Acid Cycle —

Compounds involved in cycle:
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This corresponds to:
Oxalacetate
Citrate
Isocitrate
Alpha-ketoglutamate
Succinyl-coA
Succinate
Fumarate
Malate
Enzymes involved in cycle:
CAIK Sounds So Fucking Mint.
This corresponds to:
Citrate synthase
Aconitase
Iso-citrate dehydrogenase
Alpha-Ketoglutarate dehydrogenase
Succinyl-coA synthetase
Succinate dehydrogenase
Fumerase
Malate dehydrogenase
Urea Cycle —

Compounds involved in cycle:

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This corresponds to (indented steps are either requirements or products of that step):
Ornithine
Carboamyl Phosphate
Citruline
Aspartate
Argininosuccinate
Fumarate
Arginine
Urea
Enzymes involved in cycle (OAAA are the enzymes responsible for the indented steps above):

C—OAAA
Carboamyl phosphate synthase
Ornithine transcarbamoxylase
Argininosuccinate synthase
Arginininosuccinase
Arginase
Hope these come to good use.
Monday, October 5, 2009
Posted by Konstantine

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I was born in Poland, raised in Ukraine, identify myself as Russian and now reside in Canada. How's that for an identity crisis?

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